منابع مشابه
Picking out the Details of Cerebellar LTD
Cerebellar long-term depression is thought to underlie motor learning and is mediated by internalization of AMPA receptors from the neuronal plasma membrane. In this issue of Neuron, Steinberg et al. provide firm evidence that PICK 1 and the C terminus of GluR2 are central to this process by analyzing three different transgenic mice.
متن کاملEndocannabinoids Control the Induction of Cerebellar LTD
The long-term depression (LTD) of parallel fiber (PF) synapses onto Purkinje cells plays a central role in motor learning. Endocannabinoid release and LTD induction both depend upon activation of the metabotropic glutamate receptor mGluR1, require postsynaptic calcium increases, are synapse specific, and have a similar dependence on the associative activation of PF and climbing fiber synapses. ...
متن کاملPicking Pyknons out of the Human Genome
In a recent paper in PNAS, Rigoutsos et al. (2006) describe a nonrandom pattern of repeated elements, called pyknons, which are found more frequently in the 3' untranslated regions of genes than in other regions of the human genome. Although it is unclear how pyknons might have arisen, it is possible that they may be involved in a new form of gene regulation.
متن کاملLipid Signalling: Picking Out The PIPs
Many physiological targets have been suggested for polyphosphoinositol lipids, but two out of the three monophosphorylated PIPs appeared to be no more than metabolic precursors. Recent work has shown that they also have distinct binding proteins and functions.
متن کاملReevaluating the Role of LTD in Cerebellar Motor Learning
Long-term depression at parallel fiber-Purkinje cell synapses (PF-PC LTD) has been proposed to be required for cerebellar motor learning. To date, tests of this hypothesis have sought to interfere with receptors (mGluR1) and enzymes (PKC, PKG, or αCamKII) necessary for induction of PF-PC LTD and thereby determine if cerebellar motor learning is impaired. Here, we tested three mutant mice that t...
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ژورنال
عنوان ژورنال: Neuron
سال: 2006
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2006.03.003